Eintrag in der Universitätsbibliographie der TU Chemnitz
Volltext zugänglich unter
URN: urn:nbn:de:bsz:ch1-qucosa2-738965
Aziz, Azaam
Schmidt, Oliver G. (Prof. Dr.) ; Czarske, Jürgen (Prof.) (Gutachter)
Medical Imaging of Magnetic Micromotors Through Scattering Tissues
Kurzfassung in englisch
Micro- and nanorobots (MNRs) are small autonomous devices capable of performing complex tasks and have been demonstrated for a variety of non-invasive biomedical applications, such as tissue engineering, drug delivery or assisted fertilization. However, translating such approaches to an in vivo environment is critical. Current imaging techniques do not allow localization and tracking of single or few micromotors at high spatiotemporal resolution in deep tissue.This thesis addresses some of these limitations, by exploring the use of two optical-based techniques (IR and photoacoustic imaging (PAI)) and a combination of both US and PAI. First, we employ an IR imaging setup to visualize mobile reflective micromotors under scattering phantoms and ex vivo mouse skull tissues, without using any labels. The reflective micromotor reflects more than tenfold the light intensity of a simple particle. However, the achieved penetration depth was ca. 100 μm (when using ex vivo tissues), limiting this technique to superficial biomedical applications. In this regard, PAI plays a role that combines the advantages of US such as penetration depth and real-time imaging with the molecular specificity of optics. For the first time, in this thesis, this method is evaluated for dynamic process monitoring, in particular for tracking single micromotor in real-time below ~1 cm deep phantom and ex vivo tissue.
However, the precise function control of MNRs in living organisms, demand the combination of both anatomical and functional imaging methods. Therefore, in the end, we report the use of a hybrid US and PA system for the real-time tracking of magnetically driven micromotors (single and swarms) in phantoms, ex vivo, and in vivo (in mice bladder and uterus), envisioning their application for targeted drug-delivery. This achievement is of great importance and opens the possibilities to employ medical micromotors in a living organism and perform a medical task while being externally controlled and monitored.
| Universität: | Technische Universität Chemnitz | |
| Institut: | Professur Materialsysteme der Nanoelektronik | |
| Fakultät: | Fakultät für Naturwissenschaften | |
| Dokumentart: | Dissertation | |
| Betreuer: | Schmidt, Oliver G. (Prof. Dr.) | |
| SWD-Schlagwörter: | Mikrorobotik , Bildgebendes Verfahren | |
| Freie Schlagwörter (Englisch): | medical imaging , micromotor , real-time tracking , hybrid imaging , deep tissue , in vivo imaging , microrobotics , photoacoustics , ultrasound | |
| DDC-Sachgruppe: | 621.3 | |
| Sprache: | englisch | |
| Tag der mündlichen Prüfung | 11.12.2020 |
